Endocrine Abstracts

Brown adipose tissue (BAT) was previously thought of as an animal-only tissue. Recently, this view was radically changed by several publications suggesting that active BAT might be part of normal human physiology. These results together with other papers on the same topic, make BAT-mediated dissipation of excess energy in humans a real possibility. Together, these advances are stimulating a radical reassessment of the role of brown adipose tissue in human pathophysiology. Furt...

We use redundant peptide counting as a tool to compare, quantitatively, data from mass spectrometry analyses. When combined with hierarchical clustering, a tool commonly used for micro array analysis, we can group proteins based on their relative abundance across samples. In this way, we recently completed a spatial map of the secretory pathway of rat hepatic cells comprising some 1400 different proteins, each with a defined distribution (Gilchrist, Au, Hiding et al. 20...